Anti-inflammatory Dimeric Tetrahydroxanthones from an Endophytic Muyocopron laterale.
J Nat Prod
; 85(1): 148-161, 2022 01 28.
Article
em En
| MEDLINE
| ID: mdl-35029398
ABSTRACT
Twelve new dimeric tetrahydroxanthones, muyocoxanthones A-L (1-12), were isolated from the endophytic fungus, Muyocopron laterale. Their structures were characterized on the basis of the interpretation of NMR and HRESIMS data. The absolute configurations of 1-10 and 12 were unambiguously determined by ECD spectrum data and single-crystal X-ray diffraction analysis. Compounds 2, 6, and 11 showed inhibitory activity against the LPS-induced production of nitric oxide (NO) in RAW 264.7 cells with IC50 values of 5.2, 1.3, and 5.1 µM, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ascomicetos
/
Xantonas
/
Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2022
Tipo de documento:
Article