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Randomised controlled trial of intravenous nafamostat mesylate in COVID pneumonitis: Phase 1b/2a experimental study to investigate safety, Pharmacokinetics and Pharmacodynamics.
Quinn, Tom M; Gaughan, Erin E; Bruce, Annya; Antonelli, Jean; O'Connor, Richard; Li, Feng; McNamara, Sarah; Koch, Oliver; MacKintosh, Claire; Dockrell, David; Walsh, Timothy; Blyth, Kevin G; Church, Colin; Schwarze, Jürgen; Boz, Cecilia; Valanciute, Asta; Burgess, Matthew; Emanuel, Philip; Mills, Bethany; Rinaldi, Giulia; Hardisty, Gareth; Mills, Ross; Findlay, Emily Gwyer; Jabbal, Sunny; Duncan, Andrew; Plant, Sinéad; Marshall, Adam D L; Young, Irene; Russell, Kay; Scholefield, Emma; Nimmo, Alastair F; Nazarov, Islom B; Churchill, Grant C; McCullagh, James S O; Ebrahimi, Kourosh H; Ferrett, Colin; Templeton, Kate; Rannard, Steve; Owen, Andrew; Moore, Anne; Finlayson, Keith; Shankar-Hari, Manu; Norrie, John; Parker, Richard A; Akram, Ahsan R; Anthony, Daniel C; Dear, James W; Hirani, Nik; Dhaliwal, Kevin.
Afiliação
  • Quinn TM; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Gaughan EE; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Bruce A; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Antonelli J; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • O'Connor R; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Li F; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • McNamara S; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Koch O; Regional Infectious Disease Unit, NHS Lothian, UK.
  • MacKintosh C; Regional Infectious Disease Unit, NHS Lothian, UK.
  • Dockrell D; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Regional Infectious Disease Unit, NHS Lothian, UK.
  • Walsh T; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Blyth KG; Institute of Cancer Sciences, University of Glasgow, UK.
  • Church C; Department of Respiratory Medicine, Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde Health Board, Glasgow, UK.
  • Schwarze J; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Boz C; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Valanciute A; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Burgess M; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Emanuel P; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Mills B; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Rinaldi G; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Hardisty G; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Mills R; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Findlay EG; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Jabbal S; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Duncan A; Regional Infectious Disease Unit, NHS Lothian, UK.
  • Plant S; Regional Infectious Disease Unit, NHS Lothian, UK.
  • Marshall ADL; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Young I; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Russell K; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Scholefield E; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Nimmo AF; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Nazarov IB; Latus Therapeutics, Oxford, UK; Department of Pharmacology, University of Oxford, Oxford, UK.
  • Churchill GC; Department of Pharmacology, University of Oxford, Oxford, UK.
  • McCullagh JSO; Department of Chemistry, University of Oxford, Oxford, UK.
  • Ebrahimi KH; Institute of Pharmaceutical Science, King's College London, UK.
  • Ferrett C; Department of Radiology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
  • Templeton K; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Rannard S; Centre of Excellence for Long-acting Therapeutics, Materials Innovation Factory and Department of Pharmacology and Therapeutics, University of Liverpool, UK.
  • Owen A; Centre of Excellence for Long-acting Therapeutics, Materials Innovation Factory and Department of Pharmacology and Therapeutics, University of Liverpool, UK.
  • Moore A; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Finlayson K; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Shankar-Hari M; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Norrie J; Centre for Cardiovascular Science, Queen's Medical Research Institute, Bioquarter, University of Edinburgh, Edinburgh, UK.
  • Parker RA; Edinburgh Clinical Trials Unit (ECTU), Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Akram AR; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Anthony DC; Department of Pharmacology, University of Oxford, Oxford, UK.
  • Dear JW; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh,; Centre for Cardiovascular Science, Queen's Medical Research Institute, Bioquarter, University of Edinburgh, Edinburgh, UK.
  • Hirani N; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh.
  • Dhaliwal K; Centre for Inflammation Research, Queen's Medical Research Institute, BioQuarter, University of Edinburgh, Edinburgh, UK; Royal Infirmary of Edinburgh, BioQuarter, Little France, Edinburgh,. Electronic address: Kev.Dhaliwal@ed.ac.uk.
EBioMedicine ; 76: 103856, 2022 Feb.
Article em En | MEDLINE | ID: mdl-35152152
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidinas / Anti-Inflamatórios não Esteroides / Tratamento Farmacológico da COVID-19 / Guanidinas Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzamidinas / Anti-Inflamatórios não Esteroides / Tratamento Farmacológico da COVID-19 / Guanidinas Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Ano de publicação: 2022 Tipo de documento: Article