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Safety and target engagement of an oral small-molecule sequestrant in adolescents with autism spectrum disorder: an open-label phase 1b/2a trial.
Stewart Campbell, A; Needham, Brittany D; Meyer, Christopher R; Tan, Joanna; Conrad, Mary; Preston, Gregory M; Bolognani, Federico; Rao, Srinivas G; Heussler, Helen; Griffith, Rebecca; Guastella, Adam J; Janes, Amy C; Frederick, Blaise; Donabedian, David H; Mazmanian, Sarkis K.
Afiliação
  • Stewart Campbell A; Axial Therapeutics, Woburn, MA, USA. stewart@axialtx.com.
  • Needham BD; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
  • Meyer CR; Axial Therapeutics, Woburn, MA, USA.
  • Tan J; Axial Therapeutics, Woburn, MA, USA.
  • Conrad M; Axial Therapeutics, Woburn, MA, USA.
  • Preston GM; Axial Therapeutics, Woburn, MA, USA.
  • Bolognani F; Axial Therapeutics, Woburn, MA, USA.
  • Rao SG; Axial Therapeutics, Woburn, MA, USA.
  • Heussler H; Centre for Clinical Trials in Rare Neurodevelopmental Disorders, Queensland Children's Hospital, Brisbane, QLD, Australia.
  • Griffith R; Optimal Clinical Trials, Auckland, New Zealand.
  • Guastella AJ; Brain and Mind Centre, Children's Hospital Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
  • Janes AC; Consulting Neuroscientist to Axial Therapeutics, Woburn, MA, USA.
  • Frederick B; Consulting MR Physicist to Axial Therapeutics, Woburn, MA, USA.
  • Donabedian DH; Axial Therapeutics, Woburn, MA, USA.
  • Mazmanian SK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. sarkis@caltech.edu.
Nat Med ; 28(3): 528-534, 2022 03.
Article em En | MEDLINE | ID: mdl-35165451
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbiota / Transtorno do Espectro Autista / Microbioma Gastrointestinal Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Animals / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microbiota / Transtorno do Espectro Autista / Microbioma Gastrointestinal Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adolescent / Animals / Humans Idioma: En Revista: Nat Med Assunto da revista: BIOLOGIA MOLECULAR / MEDICINA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos