Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer's disease.

Singh, Abhishek; Gupta, Parul; Tiwari, Shubhangini; Mishra, Amit; Singh, Sarika

Singh, Abhishek; Gupta, Parul; Tiwari, Shubhangini; Mishra, Amit; Singh, Sarika.

Afiliação

Singh A; Division of Toxicology and Experimental Medicine, Department of Neurosciences and Ageing Biology, CSIR-Central Drug Research Institute, Lucknow-226031, UP, India.
Gupta P; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India.
Tiwari S; Division of Toxicology and Experimental Medicine, Department of Neurosciences and Ageing Biology, CSIR-Central Drug Research Institute, Lucknow-226031, UP, India.
Mishra A; Academy of Scientific & Innovative Research (AcSIR), Ghaziabad-201002, India.
Singh S; Division of Toxicology and Experimental Medicine, Department of Neurosciences and Ageing Biology, CSIR-Central Drug Research Institute, Lucknow-226031, UP, India.

Cell Tissue Res ; 388(2): 239-258, 2022 May.

Article em En | MEDLINE | ID: mdl-35195784

Assuntos

Doença de Alzheimer; Acetilcolinesterase/metabolismo; Doença de Alzheimer/tratamento farmacológico; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Animais; Biomarcadores/metabolismo; Morte Celular; Guanabenzo/metabolismo; Guanabenzo/uso terapêutico; Humanos; Neurônios/metabolismo; Ratos

Palavras-chave

Acetylcholinesterase; Alzheimer's disease; Apoptosis; Donepezil; Endoplasmic reticulum stress; Guanabenz; Mitochondrial activity; Repurposing of drug; Streptozotocin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Tissue Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Índia

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