Clinical response of CARD14-associated papulosquamous eruption to an anti-interleukin-17A antibody.
Br J Dermatol
; 187(3): 419-422, 2022 09.
Article
em En
| MEDLINE
| ID: mdl-35262907
Here we present another family with CARD14-associated papulosquamous eruption, which is characterized by mutations in CARD14 and skin lesions resembling psoriasis and pityriasis rubra pilaris. We show beneficial therapeutic response to anti-IL17A treatment in one patient and performed immunomonitoring of our patient, exhibiting enhanced pSTAT3 levels in T cells before treatment, which normalized after treatment. Together, our data support the pathogenic role of IL-17A in this disease, which might have consequences for future treatment decisions in this rare condition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pitiríase Rubra Pilar
/
Psoríase
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Exantema
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Br J Dermatol
Ano de publicação:
2022
Tipo de documento:
Article