The expanding universe of PARP1-mediated molecular and therapeutic mechanisms.

Huang, Dan; Kraus, W Lee

Huang, Dan; Kraus, W Lee.

Afiliação

Huang D; Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. Electronic address: huangda
Kraus WL; Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Division of Basic Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: lee.kraus@utsouthwestern.edu.

Mol Cell ; 82(12): 2315-2334, 2022 06 16.

Article em En | MEDLINE | ID: mdl-35271815

Assuntos

ADP-Ribosilação; Reparo do DNA; Cromatina/genética; Dano ao DNA; Poli(ADP-Ribose) Polimerase-1/genética; Poli(ADP-Ribose) Polimerase-1/metabolismo; Processamento de Proteína Pós-Traducional; RNA/metabolismo

Palavras-chave

ADP-ribosylation; DNA damage response; DNA replication; PARP; PARP inhibitor; PARPi; PTM; RNA biology; biomolecular condensate; chromatin; gene regulation; histone; poly(ADP-ribose) polymerase; post-translational modification; ribosome biogenesis; therapeutic resistance; therapeutics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Reparo do DNA / ADP-Ribosilação Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2022 Tipo de documento: Article

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