Your browser doesn't support javascript.
loading
Exerkines in health, resilience and disease.
Chow, Lisa S; Gerszten, Robert E; Taylor, Joan M; Pedersen, Bente K; van Praag, Henriette; Trappe, Scott; Febbraio, Mark A; Galis, Zorina S; Gao, Yunling; Haus, Jacob M; Lanza, Ian R; Lavie, Carl J; Lee, Chih-Hao; Lucia, Alejandro; Moro, Cedric; Pandey, Ambarish; Robbins, Jeremy M; Stanford, Kristin I; Thackray, Alice E; Villeda, Saul; Watt, Matthew J; Xia, Ashley; Zierath, Juleen R; Goodpaster, Bret H; Snyder, Michael P.
Afiliação
  • Chow LS; Division of Diabetes Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN, USA. chow0007@umn.edu.
  • Gerszten RE; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Taylor JM; Department of Pathology, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.
  • Pedersen BK; Centre of Inflammation and Metabolism/Centre for PA Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • van Praag H; Stiles-Nicholson Brain institute and Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter, FL, USA.
  • Trappe S; Human Performance Laboratory, Ball State University, Muncie, IN, USA.
  • Febbraio MA; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
  • Galis ZS; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Gao Y; Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
  • Haus JM; School of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
  • Lanza IR; Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
  • Lavie CJ; Division of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-the University of Queensland School of Medicine, New Orleans, LA, USA.
  • Lee CH; Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
  • Lucia A; Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.
  • Moro C; Research Institute Hospital 12 de Octubre ('imas12'), Madrid, Spain.
  • Pandey A; CIBER en Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain.
  • Robbins JM; Institute of Metabolic and Cardiovascular Diseases, Team MetaDiab, Inserm UMR1297, Toulouse, France.
  • Stanford KI; Toulouse III University-Paul Sabatier (UPS), Toulouse, France.
  • Thackray AE; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
  • Villeda S; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Watt MJ; Department of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.
  • Xia A; National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.
  • Zierath JR; Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
  • Goodpaster BH; Department of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Victoria, Australia.
  • Snyder MP; Division of Diabetes, Endocrinology, & Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Nat Rev Endocrinol ; 18(5): 273-289, 2022 05.
Article em En | MEDLINE | ID: mdl-35304603
ABSTRACT
The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines). Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. As such, exerkines have potential for the treatment of cardiovascular disease, type 2 diabetes mellitus and obesity, and possibly in the facilitation of healthy ageing. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Rev Endocrinol Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Tipo 2 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Nat Rev Endocrinol Assunto da revista: ENDOCRINOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos