Freeze-Dried Biopharmaceutical Formulations are Surprisingly Less Stable than Liquid Formulations during Dropping.

Fang, Wei-Jie; Pang, Meng-Juan; Liu, Jia-Wei; Wang, Xinyu; Wang, Haibin; Sun, Min-Fei

Fang, Wei-Jie; Pang, Meng-Juan; Liu, Jia-Wei; Wang, Xinyu; Wang, Haibin; Sun, Min-Fei.

Afiliação

Fang WJ; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. wjfang@zju.edu.cn.
Pang MJ; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016, China. wjfang@zju.edu.cn.
Liu JW; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Wang X; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016, China.
Wang H; Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Sun MF; Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016, China.

Pharm Res ; 39(4): 795-803, 2022 Apr.

Article em En | MEDLINE | ID: mdl-35314998

Assuntos

Produtos Biológicos; Anticorpos Monoclonais/química; Estabilidade de Medicamentos; Liofilização; Pós

Palavras-chave

biopharmaceutical formulation; dropping; free radical; freeze-dry; protein aggregation; specific heat capacity; sub-visible particle

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos Idioma: En Revista: Pharm Res Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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