Computational Analysis of Cytokine Release Following Bispecific T-Cell Engager Therapy: Applications of a Logic-Based Model.

Selvaggio, Gianluca; Parolo, Silvia; Bora, Pranami; Leonardelli, Lorena; Harrold, John; Mehta, Khamir; Rock, Dan A; Marchetti, Luca

Selvaggio, Gianluca; Parolo, Silvia; Bora, Pranami; Leonardelli, Lorena; Harrold, John; Mehta, Khamir; Rock, Dan A; Marchetti, Luca.

Afiliação

Selvaggio G; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Parolo S; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Bora P; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Leonardelli L; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
Harrold J; Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, CA, United States.
Mehta K; Quantitative Pharmacology & Disposition, Seattle Genetics, San Francisco, CA, United States.
Rock DA; Clinical Pharmacology, Modeling and Simulation, Amgen Inc., South San Francisco, CA, United States.
Marchetti L; Pharmacokinetics and Drug Metabolism, Amgen Inc., South San Francisco, CA, United States.

Front Oncol ; 12: 818641, 2022.

Article em En | MEDLINE | ID: mdl-35350575

Palavras-chave

CRS; QSP modeling; cancer immunotherapy; cytokine release syndrome; logical modeling

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Front Oncol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália

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