Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of <i>SMN2</i> in SMA Type I Fibroblasts.

Toosaranont, Jarichad; Ruschadaariyachat, Sukanya; Mujchariyakul, Warasinee; Arora, Jantarika Kumar; Charoensawan, Varodom; Suktitipat, Bhoom; Palmer, Thomas N; Fletcher, Sue; Wilton, Steve D; Mitrpant, Chalermchai

Antisense Oligonucleotide Induction of the hnRNPA1b Isoform Affects Pre-mRNA Splicing of SMN2 in SMA Type I Fibroblasts.

Toosaranont, Jarichad; Ruschadaariyachat, Sukanya; Mujchariyakul, Warasinee; Arora, Jantarika Kumar; Charoensawan, Varodom; Suktitipat, Bhoom; Palmer, Thomas N; Fletcher, Sue; Wilton, Steve D; Mitrpant, Chalermchai.

Afiliação

Toosaranont J; Department of Biochemistry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Ruschadaariyachat S; Department of Biochemistry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Mujchariyakul W; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10700, Thailand.
Arora JK; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10700, Thailand.
Charoensawan V; Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10700, Thailand.
Suktitipat B; Integrative Computational BioScience (ICBS) Center, Mahidol University, Nakhon Pathom 73170, Thailand.
Palmer TN; Systems Biology of Diseases Research Unit, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
Fletcher S; Department of Biochemistry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Wilton SD; Integrative Computational BioScience (ICBS) Center, Mahidol University, Nakhon Pathom 73170, Thailand.
Mitrpant C; Perron Institute for Neurological and Translational Science, The University of Western Australia, Perth, WA 6009, Australia.

Int J Mol Sci ; 23(7)2022 Apr 01.

Article em En | MEDLINE | ID: mdl-35409296

Assuntos

Atrofia Muscular Espinal; Atrofias Musculares Espinais da Infância; Fibroblastos/metabolismo; Humanos; Atrofia Muscular Espinal/metabolismo; Oligonucleotídeos/farmacologia; Oligonucleotídeos Antissenso/genética; Oligonucleotídeos Antissenso/metabolismo; Oligonucleotídeos Antissenso/farmacologia; Isoformas de Proteínas/metabolismo; Precursores de RNA/genética; Precursores de RNA/metabolismo; Splicing de RNA; Proteína 1 de Sobrevivência do Neurônio Motor/genética; Proteína 2 de Sobrevivência do Neurônio Motor/genética; Proteína 2 de Sobrevivência do Neurônio Motor/metabolismo

Palavras-chave

antisense oligonucleotide; hnRNPA1; phosphorodiamidate morpholino oligomer; spinal muscular atrophy; transcriptome

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Atrofia Muscular Espinal / Atrofias Musculares Espinais da Infância Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Tailândia

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