Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the G&#945;i-2-PKA-ASK1 signaling pathway.

Lan, Tian; Wu, Yuhan; Zhang, Yulei; Li, Shuhan; Zhu, Zhanpeng; Wang, Liyan; Mao, Xueqin; Li, Ye; Fan, Cuiqin; Wang, Wenjing; Yu, Shu Yan

Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway.

Lan, Tian; Wu, Yuhan; Zhang, Yulei; Li, Shuhan; Zhu, Zhanpeng; Wang, Liyan; Mao, Xueqin; Li, Ye; Fan, Cuiqin; Wang, Wenjing; Yu, Shu Yan.

Afiliação

Lan T; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Wu Y; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Zhang Y; Jinan International Travel Healthcare Center, Wenhuadonglu Road 62#, Jinan, Shandong Province, 250012, People's Republic of China.
Li S; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Zhu Z; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Wang L; Morphological Experimental Center, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Mao X; Department of Psychology, Qilu Hospital of Shandong University, 107 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Li Y; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Fan C; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Wang W; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China.
Yu SY; Department of Physiology, School of Basic Medical Sciences, Shandong University, 44 Wenhuaxilu Road, Jinan, Shandong Province, 250012, People's Republic of China. shuyanyu@sdu.edu.cn.

J Neuroinflammation ; 19(1): 117, 2022 May 24.

Article em En | MEDLINE | ID: mdl-35610704

Assuntos

Acetamidas; Naftalenos; Receptor 5-HT2C de Serotonina; Acetamidas/farmacologia; Animais; Antidepressivos/farmacologia; Depressão/induzido quimicamente; Depressão/tratamento farmacológico; Depressão/patologia; Subunidades alfa Gi-Go de Proteínas de Ligação ao GTP/metabolismo; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Lipopolissacarídeos/farmacologia; MAP Quinase Quinase Quinase 5/metabolismo; Naftalenos/farmacologia; Neurônios/efeitos dos fármacos; Neurônios/patologia; Ratos; Receptor 5-HT2C de Serotonina/metabolismo; Transdução de Sinais

Palavras-chave

5-HT2C receptor; Agomelatine; Apoptosis; Depression; Gαi-2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor 5-HT2C de Serotonina / Acetamidas / Naftalenos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Neuroinflammation Assunto da revista: NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article

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