Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water.

Singh, Jyoti; Whitaker, Daniel; Thoma, Benjamin; Islam, Saidul; Foden, Callum S; Aliev, Abil E; Sheppard, Tom D; Powner, Matthew W

Singh, Jyoti; Whitaker, Daniel; Thoma, Benjamin; Islam, Saidul; Foden, Callum S; Aliev, Abil E; Sheppard, Tom D; Powner, Matthew W.

Afiliação

Singh J; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Whitaker D; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Thoma B; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Islam S; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Foden CS; Department of Chemistry, King's College London, 7 Trinity Street, London SE1 1DB, United Kingdom.
Aliev AE; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Sheppard TD; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.
Powner MW; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, United Kingdom.

J Am Chem Soc ; 144(23): 10151-10155, 2022 06 15.

Article em En | MEDLINE | ID: mdl-35640067

Assuntos

Amidas; Lisina; Amidinas; Catálise; Hidrólise; Peptídeos/química; Prebióticos; Compostos de Sulfidrila/química; Água

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Amidas / Lisina Idioma: En Revista: J Am Chem Soc Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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