Enoxacin-based derivatives: antimicrobial and antibiofilm agent: a biology-oriented drug synthesis (BIODS) approach.
Future Med Chem
; 14(13): 947-962, 2022 07.
Article
em En
| MEDLINE
| ID: mdl-35695000
ABSTRACT
Background:
To find alternative molecules against Klebsiella pneumonia, Proteus mirabilis and methicillin-resistant Staphylococcus aureus, new enoxacin derivatives were synthesized and screened.Methods:
All derivatives exhibited promising antibacterial activities as compared to standard enoxacin (2 µg/ml) and standard cefixime (82 µg/ml). Compounds 2, 3 and 5 significantly downregulated the gene expression of biofilm-forming genes.Conclusion:
Based on our results, these molecules may serve as potential drug candidates to cure several bacterial infections in the future.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus Resistente à Meticilina
Idioma:
En
Revista:
Future Med Chem
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Paquistão