Synthesis and biological evaluation of 4H-benzo[e][1,3]oxazin-4-ones analogues of TGX-221 as inhibitors of PI3Kß.

Mohammed, Ehtesham U R; Porter, Zoe J; Jennings, Ian G; Al-Rawi, Jasim M A; Thompson, Philip E; Angove, Michael J

Mohammed, Ehtesham U R; Porter, Zoe J; Jennings, Ian G; Al-Rawi, Jasim M A; Thompson, Philip E; Angove, Michael J.

Afiliação

Mohammed EUR; Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Science, La Trobe University, P.O. Box 199, Bendigo, VIC 3552, Australia. Electronic address: ehteshamchem@gmail.com.
Porter ZJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
Jennings IG; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
Al-Rawi JMA; Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Science, La Trobe University, P.O. Box 199, Bendigo, VIC 3552, Australia.
Thompson PE; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia.
Angove MJ; Pharmacy and Biomedical Sciences, La Trobe Institute for Molecular Science, La Trobe University, P.O. Box 199, Bendigo, VIC 3552, Australia.

Bioorg Med Chem ; 69: 116832, 2022 09 01.

Article em En | MEDLINE | ID: mdl-35752141

Assuntos

Morfolinas; Pirimidinonas; Pirimidinonas/farmacologia; Relação Estrutura-Atividade

Palavras-chave

1,3-Benzoxazin-4-ones; Anticancer; PI3Kß

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinonas / Morfolinas Idioma: En Revista: Bioorg Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2022 Tipo de documento: Article

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