Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.

Soyama, Hirotoshi; Nishio, Miki; Otani, Junji; Sakuma, Toshiko; Takao, Shintaro; Hara, Shigeo; Masuda, Takaaki; Mimori, Koshi; Toyokuni, Shinya; Lydon, John P; Nakao, Kazuwa; Nishina, Hiroshi; Fukumoto, Takumi; Maehama, Tomohiko; Suzuki, Akira

Soyama, Hirotoshi; Nishio, Miki; Otani, Junji; Sakuma, Toshiko; Takao, Shintaro; Hara, Shigeo; Masuda, Takaaki; Mimori, Koshi; Toyokuni, Shinya; Lydon, John P; Nakao, Kazuwa; Nishina, Hiroshi; Fukumoto, Takumi; Maehama, Tomohiko; Suzuki, Akira.

Afiliação

Soyama H; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
Nishio M; Division of Hepato-Biliary and Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
Otani J; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
Sakuma T; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
Takao S; Department of Pathology, Hyogo Cancer Center, Akashi, Hyogo 673-8558, Japan.
Hara S; Department of Breast Surgery, Hyogo Cancer Center, Akashi, Hyogo 673-8558, Japan.
Masuda T; Department of Diagnostic Pathology, Kobe City Medical Center General Hospital, Kobe, Hyogo 650-0047, Japan.
Mimori K; Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874-0838, Japan.
Toyokuni S; Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874-0838, Japan.
Lydon JP; Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
Nakao K; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
Nishina H; Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Kyoto 606-8397, Japan.
Fukumoto T; Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Tokyo 113-8510, Japan.
Maehama T; Division of Hepato-Biliary and Pancreatic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.
Suzuki A; Division of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Hyogo 650-0017, Japan.

Proc Natl Acad Sci U S A ; 119(29): e2123134119, 2022 07 19.

Article em En | MEDLINE | ID: mdl-35858357

Assuntos

Via de Sinalização Hippo; Neoplasias Mamárias Experimentais; Lesões Pré-Cancerosas; Neoplasias de Mama Triplo Negativas; Proteínas Adaptadoras de Transdução de Sinal/genética; Animais; Carcinogênese/genética; Linhagem Celular Tumoral; Feminino; Deleção de Genes; Via de Sinalização Hippo/genética; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/genética; Neoplasias Mamárias Experimentais/genética; Camundongos; Lesões Pré-Cancerosas/genética; Receptores de Estrogênio/genética; Proteínas com Motivo de Ligação a PDZ com Coativador Transcricional; Neoplasias de Mama Triplo Negativas/genética; Proteína Supressora de Tumor p53/genética; Proteínas de Sinalização YAP/genética

Palavras-chave

Hippo; MOB1; TAZ; basal-like breast cancer; triple-negative breast cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Neoplasias de Mama Triplo Negativas / Via de Sinalização Hippo / Neoplasias Mamárias Experimentais Limite: Animals / Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

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