A Novel ERK2 Degrader Z734 Induces Apoptosis of MCF-7 Cells via the HERC3/p53 Signaling Pathway.

Xu, Shiyao; Xiong, Yan; Yao, Rui; Tian, Rong; Meng, Zhuqing; Zaky, Mohamed Y; Fu, Beibei; Guo, Dong; Wang, Lulu; Lin, Feng; Lin, Xiaoyuan; Wu, Haibo

Xu, Shiyao; Xiong, Yan; Yao, Rui; Tian, Rong; Meng, Zhuqing; Zaky, Mohamed Y; Fu, Beibei; Guo, Dong; Wang, Lulu; Lin, Feng; Lin, Xiaoyuan; Wu, Haibo.

Afiliação

Xu S; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Xiong Y; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Yao R; Department of Pathology, Chongqing Hygeia Hospital, Chongqing 401331, China.
Tian R; Department of Pathology, Chongqing Hygeia Hospital, Chongqing 401331, China.
Meng Z; Department of Pharmacy, Mianyang Fulin Hospital, Mianyang 621000, China.
Zaky MY; Molecular Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef 62511, Egypt.
Fu B; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Guo D; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Wang L; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Lin F; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Lin X; School of Life Sciences, Chongqing University, Chongqing 401331, China.
Wu H; School of Life Sciences, Chongqing University, Chongqing 401331, China.

Molecules ; 27(14)2022 Jul 06.

Article em En | MEDLINE | ID: mdl-35889210

Assuntos

Neoplasias da Mama; Proteína Quinase 1 Ativada por Mitógeno; Animais; Apoptose; Neoplasias da Mama/metabolismo; Linhagem Celular Tumoral; Feminino; Humanos; Células MCF-7; Camundongos; Proteína Quinase 1 Ativada por Mitógeno/metabolismo; Fosforilação; Transdução de Sinais; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Ubiquitina-Proteína Ligases/metabolismo

Palavras-chave

ERK2 degrader; HERC3; apoptosis; breast cancer; p53; synergy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Proteína Quinase 1 Ativada por Mitógeno Limite: Animals / Female / Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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