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Replicating RNA platform enables rapid response to the SARS-CoV-2 Omicron variant and elicits enhanced protection in naïve hamsters compared to ancestral vaccine.
Hawman, David W; Meade-White, Kimberly; Clancy, Chad; Archer, Jacob; Hinkley, Troy; Leventhal, Shanna S; Rao, Deepashri; Stamper, Allie; Lewis, Matthew; Rosenke, Rebecca; Krieger, Kyle; Randall, Samantha; Khandhar, Amit P; Hao, Linhue; Hsiang, Tien-Ying; Greninger, Alexander L; Gale, Michael; Berglund, Peter; Fuller, Deborah Heydenburg; Rosenke, Kyle; Feldmann, Heinz; Erasmus, Jesse H.
Afiliação
  • Hawman DW; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. Electronic address: david.hawman@nih.gov.
  • Meade-White K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Clancy C; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Archer J; HDT Bio, Seattle, WA 98102, USA.
  • Hinkley T; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Leventhal SS; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Rao D; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Stamper A; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Lewis M; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Rosenke R; Rocky Mountain Veterinary Branch, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Krieger K; HDT Bio, Seattle, WA 98102, USA.
  • Randall S; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Khandhar AP; HDT Bio, Seattle, WA 98102, USA.
  • Hao L; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Hsiang TY; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Greninger AL; Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Gale M; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Berglund P; HDT Bio, Seattle, WA 98102, USA.
  • Fuller DH; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA.
  • Rosenke K; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA.
  • Feldmann H; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT 59840, USA. Electronic address: feldmannh@niaid.nih.gov.
  • Erasmus JH; HDT Bio, Seattle, WA 98102, USA; Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address: jesse.erasmus@hdt.bio.
EBioMedicine ; 83: 104196, 2022 Sep.
Article em En | MEDLINE | ID: mdl-35932641
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Virais / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: EBioMedicine Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas Virais / COVID-19 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: EBioMedicine Ano de publicação: 2022 Tipo de documento: Article