Combining FLASH and spatially fractionated radiation therapy: The best of both worlds.
Radiother Oncol
; 175: 169-177, 2022 10.
Article
em En
| MEDLINE
| ID: mdl-35952978
ABSTRACT
FLASH radiotherapy (FLASH-RT) and spatially fractionated radiation therapy (SFRT) are two new therapeutical strategies that use non-standard dose delivery methods to reduce normal tissue toxicity and increase the therapeutic index. Although likely based on different mechanisms, both FLASH-RT and SFRT have shown to elicit radiobiological effects that significantly differ from those induced by conventional radiotherapy. With the therapeutic potential having been established separately for each technique, the combination of FLASH-RT and SFRT could therefore represent a winning alliance. In this review, we discuss the state of the art, advantages and current limitations, potential synergies, and where a combination of these two techniques could be implemented today or in the near future.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fracionamento da Dose de Radiação
Limite:
Humans
Idioma:
En
Revista:
Radiother Oncol
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França