Cerebral blood flow and cardiovascular risk effects on resting brain regional homogeneity.
Neuroimage
; 262: 119555, 2022 11 15.
Article
em En
| MEDLINE
| ID: mdl-35963506
ABSTRACT
Regional homogeneity (ReHo) is a measure of local functional brain connectivity that has been reported to be altered in a wide range of neuropsychiatric disorders. Computed from brain resting-state functional MRI time series, ReHo is also sensitive to fluctuations in cerebral blood flow (CBF) that in turn may be influenced by cerebrovascular health. We accessed cerebrovascular health with Framingham cardiovascular risk score (FCVRS). We hypothesize that ReHo signal may be influenced by regional CBF; and that these associations can be summarized as FCVRSâCBFâReHo. We used three independent samples to test this hypothesis. A test-retest sample of Nâ¯=â¯30 healthy volunteers was used for test-retest evaluation of CBF effects on ReHo. Amish Connectome Project (ACP) sample (Nâ¯=â¯204, healthy individuals) was used to evaluate association between FCVRS and ReHo and testing if the association diminishes given CBF. The UKBB sample (Nâ¯=â¯6,285, healthy participants) was used to replicate the effects of FCVRS on ReHo. We observed strong CBFâReHo links (p<2.5â¯×â¯10-3) using a three-point longitudinal sample. In ACP sample, marginal and partial correlations analyses demonstrated that both CBF and FCVRS were significantly correlated with the whole-brain average (p<10-6) and regional ReHo values, with the strongest correlations observed in frontal, parietal, and temporal areas. Yet, the association between ReHo and FCVRS became insignificant once the effect of CBF was accounted for. In contrast, CBFâReHo remained significantly linked after adjusting for FCVRS and demographic covariates (p<10-6). Analysis in Nâ¯=â¯6,285 replicated the FCVRSâReHo effect (pâ¯=â¯2.7â¯×â¯10-27). In summary, ReHo alterations in health and neuropsychiatric illnesses may be partially driven by region-specific variability in CBF, which is, in turn, influenced by cardiovascular factors.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Conectoma
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Neuroimage
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2022
Tipo de documento:
Article