The epigenetic impact of suberohydroxamic acid and 5­Aza­2'­deoxycytidine on DNMT3B expression in myeloma cell lines differing in IL­6 expression.

Trtkova, Katerina Smesny; Luzna, Petra; Drozdkova, Denisa Weiser; Cizkova, Katerina; Janovska, Lucie; Gursky, Jan; Prukova, Dana; Frydrych, Ivo; Hajduch, Marian; Minarik, Jiri

The epigenetic impact of suberohydroxamic acid and 5Aza2'deoxycytidine on DNMT3B expression in myeloma cell lines differing in IL6 expression.

Trtkova, Katerina Smesny; Luzna, Petra; Drozdkova, Denisa Weiser; Cizkova, Katerina; Janovska, Lucie; Gursky, Jan; Prukova, Dana; Frydrych, Ivo; Hajduch, Marian; Minarik, Jiri.

Afiliação

Trtkova KS; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Luzna P; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Drozdkova DW; Department of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Cizkova K; Department of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Janovska L; Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Gursky J; Department of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Prukova D; Institute of Pathological Physiology, First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
Frydrych I; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, 779 00 Olomouc, Czech Republic.
Hajduch M; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, 779 00 Olomouc, Czech Republic.
Minarik J; Department of HematoOncology, University Hospital Olomouc, 779 00 Olomouc, Czech Republic.

Mol Med Rep ; 26(4)2022 Oct.

Article em En | MEDLINE | ID: mdl-36043519

Assuntos

DNA (Citosina-5-)-Metiltransferases; Decitabina; Epigênese Genética; Mieloma Múltiplo; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Linhagem Celular Tumoral; Inibidor de Quinase Dependente de Ciclina p15/genética; Inibidor de Quinase Dependente de Ciclina p15/metabolismo; Inibidor p16 de Quinase Dependente de Ciclina/genética; Inibidor p16 de Quinase Dependente de Ciclina/metabolismo; DNA (Citosina-5-)-Metiltransferases/genética; DNA (Citosina-5-)-Metiltransferases/metabolismo; Metilação de DNA; Decitabina/farmacologia; Inativação Gênica; Humanos; Interleucina-6/genética; Interleucina-6/metabolismo; Mieloma Múltiplo/genética; Mieloma Múltiplo/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; DNA Metiltransferase 3B

Palavras-chave

DNA methylation; cyclindependent kinase inhibitor; interleukin6; multiple myeloma cell lines

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Epigênese Genética / DNA (Citosina-5-)-Metiltransferases / Decitabina / Mieloma Múltiplo Limite: Humans Idioma: En Revista: Mol Med Rep Ano de publicação: 2022 Tipo de documento: Article País de afiliação: República Tcheca

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google