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Heterozygous LRP1 deficiency causes developmental dysplasia of the hip by impairing triradiate chondrocytes differentiation due to inhibition of autophagy.
Yan, Wenjin; Zheng, Liming; Xu, Xingquan; Hao, Zheng; Zhang, Yibo; Lu, Jun; Sun, Ziying; Dai, Jin; Shi, Dongquan; Guo, Baosheng; Jiang, Qing.
Afiliação
  • Yan W; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, PR China.
  • Zheng L; Branch of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, 210008, PR China.
  • Xu X; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, PR China.
  • Hao Z; Branch of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, 210008, PR China.
  • Zhang Y; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, PR China.
  • Lu J; Branch of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, 210008, PR China.
  • Sun Z; Nanjing Zhongyangmen Community Health Service Center, Kang'ai Hospital, Nanjing, 210037, China.
  • Dai J; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, PR China.
  • Shi D; Branch of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, 210008, PR China.
  • Guo B; State Key Laboratory of Pharmaceutical Biotechnology, Division of Sports Medicine and Adult Reconstructive Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu, PR China.
  • Jiang Q; Branch of National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, 210008, PR China.
Proc Natl Acad Sci U S A ; 119(37): e2203557119, 2022 09 13.
Article em En | MEDLINE | ID: mdl-36067312
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Condrócitos / Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Displasia do Desenvolvimento do Quadril / Heterozigoto Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Condrócitos / Proteína-1 Relacionada a Receptor de Lipoproteína de Baixa Densidade / Displasia do Desenvolvimento do Quadril / Heterozigoto Tipo de estudo: Etiology_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article