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Associations of Immunogenicity and Reactogenicity After Severe Acute Respiratory Syndrome Coronavirus 2 mRNA-1273 Vaccine in the COVE and TeenCOVE Trials.
Siangphoe, Uma; Baden, Lindsey R; El Sahly, Hana M; Essink, Brandon; Ali, Kashif; Berman, Gary; Tomassini, Joanne E; Deng, Weiping; Pajon, Rolando; McPhee, Roderick; Dixit, Avika; Das, Rituparna; Miller, Jacqueline M; Zhou, Honghong.
Afiliação
  • Siangphoe U; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • Baden LR; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • El Sahly HM; Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
  • Essink B; Meridian Clinical Research, Savannah, Georgia, USA.
  • Ali K; Kool Kids Pediatrics, DM Clinical Research, Houston, Texas, USA.
  • Berman G; The Clinical Research Institute, Minneapolis, Minnesota, USA.
  • Tomassini JE; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • Deng W; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • Pajon R; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • McPhee R; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • Dixit A; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • Das R; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • Miller JM; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
  • Zhou H; Infectious Disease Development, Moderna, Cambridge, Massachusetts, USA.
Clin Infect Dis ; 76(2): 271-280, 2023 01 13.
Article em En | MEDLINE | ID: mdl-36130187
BACKGROUND: The reactogenicity and immunogenicity of coronavirus disease 2019 (COVID-19) vaccines are well studied. Little is known regarding the relationship between immunogenicity and reactogenicity of COVID-19 vaccines. METHODS: This study assessed the association between immunogenicity and reactogenicity after 2 mRNA-1273 (100 µg) injections in 1671 total adolescent and adult participants (≥12 years) from the primary immunogenicity sets of the blinded periods of the Coronavirus Efficacy (COVE) and TeenCOVE trials. Associations between immunogenicity through day 57 and solicited adverse reactions (ARs) after the first and second injections of mRNA-1273 were evaluated among participants with and without solicited ARs using linear mixed-effects models. RESULTS: mRNA-1273 reactogenicity in this combined analysis set was similar to that reported for these trials. The vaccine elicited high neutralizing antibody (nAb) geometric mean titers (GMTs) in evaluable participants. GMTs at day 57 were significantly higher in participants who experienced solicited systemic ARs after the second injection (1227.2 [1164.4-1293.5]) than those who did not (980.1 [886.8-1083.2], P = .001) and were associated with fever, chills, headache, fatigue, myalgia, and arthralgia. Significant associations with local ARs were not found. CONCLUSIONS: These data show an association of systemic ARs with increased nAb titers following a second mRNA-1273 injection. While these data indicate systemic ARs are associated with increased antibody titers, high nAb titers were observed in participants after both injections, consistent with the immunogenicity and efficacy in these trials. These results add to the body of evidence regarding the relationship of immunogenicity and reactogenicity and can contribute toward the design of future mRNA vaccines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vacinas contra COVID-19 / COVID-19 Tipo de estudo: Risk_factors_studies Limite: Adolescent / Adult / Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos