DANCR deletion retards the initiation and progression of hepatocellular carcinoma based on gene knockout and patient-derived xenograft in situ hepatoma mice model.

Gan, Xiaojie; Ding, Dongyang; Wang, Mengchao; Yang, Yuan; Sun, Dapeng; Li, Wen; Ding, Wenbin; Yang, Fu; Zhou, Weiping; Yuan, Shengxian

Gan, Xiaojie; Ding, Dongyang; Wang, Mengchao; Yang, Yuan; Sun, Dapeng; Li, Wen; Ding, Wenbin; Yang, Fu; Zhou, Weiping; Yuan, Shengxian.

Afiliação

Gan X; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China.
Ding D; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China.
Wang M; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China.
Yang Y; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China.
Sun D; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China.
Li W; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China.
Ding W; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China.
Yang F; The Department of Medical Genetics, Naval Medical University, 800 Xiangyin Road, Shanghai, 200433, China. Electronic address: yangfusq1997@smmu.edu.cn.
Zhou W; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China. Electronic address: ehphwp@126.com.
Yuan S; The Third Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, 225 Changhai Road, Shanghai, 200438, China. Electronic address: yuanshengx@126.com.

Cancer Lett ; 550: 215930, 2022 12 01.

Article em En | MEDLINE | ID: mdl-36183859

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; MicroRNAs; RNA Longo não Codificante; Animais; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; Proliferação de Células/genética; Modelos Animais de Doenças; Regulação Neoplásica da Expressão Gênica; Técnicas de Inativação de Genes; Xenoenxertos; Humanos; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/patologia; Camundongos; MicroRNAs/genética; Estudos Prospectivos; RNA Guia de Cinetoplastídeos; RNA Longo não Codificante/genética; RNA Longo não Codificante/metabolismo; RNA Interferente Pequeno

Palavras-chave

AAV; DANCR; Gene knockout; Hepatocellular carcinoma; PDX

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / MicroRNAs / RNA Longo não Codificante / Neoplasias Hepáticas Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Cancer Lett Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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