Methylglyoxal induces multiple serine phosphorylation in insulin receptor substrate 1 via the TAK1-p38-mTORC1 signaling axis in adipocytes.

Ng, Su-Ping; Nomura, Wataru; Takahashi, Haruya; Inoue, Kazuo; Kawada, Teruo; Goto, Tsuyoshi; Inoue, Yoshiharu

Ng, Su-Ping; Nomura, Wataru; Takahashi, Haruya; Inoue, Kazuo; Kawada, Teruo; Goto, Tsuyoshi; Inoue, Yoshiharu.

Afiliação

Ng SP; Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Nomura W; Laboratory of Molecular Microbiology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Takahashi H; Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Inoue K; Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Kawada T; Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Goto T; Laboratory of Molecular Function of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.
Inoue Y; Laboratory of Molecular Microbiology, Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Uji, Kyoto 611-0011, Japan.

Biochem J ; 479(21): 2279-2296, 2022 11 11.

Article em En | MEDLINE | ID: mdl-36256829

Assuntos

Resistência à Insulina; Aldeído Pirúvico; Humanos; Proteínas Substratos do Receptor de Insulina/genética; Proteínas Substratos do Receptor de Insulina/metabolismo; Aldeído Pirúvico/farmacologia; Aldeído Pirúvico/metabolismo; Resistência à Insulina/fisiologia; Serina/metabolismo; Transdução de Sinais/fisiologia; Adipócitos/metabolismo; Insulina/farmacologia; Insulina/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Tirosina/metabolismo; Fosfoproteínas/metabolismo

Palavras-chave

TAK1; adipocytes; insulin signalling; mTOR; methylglyoxal; signalling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aldeído Pirúvico / Resistência à Insulina Limite: Humans Idioma: En Revista: Biochem J Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Japão

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