Correlation between initial tumor enlargement and magnetic resonance imaging characteristics following linear accelerator-based stereotactic radiosurgery for acoustic neuromas.
Strahlenther Onkol
; 199(8): 718-726, 2023 08.
Article
em En
| MEDLINE
| ID: mdl-36326857
ABSTRACT
BACKGROUND:
Initial tumor enlargement (or pseudoprogression) instead of true tumor progression is a common phenomenon in patients with acoustic neuromas who are treated with stereotactic radiosurgery (SRS). This phenomenon can affect clinical decision-making and patient management. This study assessed the correlation between initial tumor enlargement and magnetic resonance imaging characteristics in patients with acoustic neuromas who were treated with linear accelerator (LINAC)-based SRS. The long-term tumor control outcomes were also analyzed. MATERIALS ANDMETHODS:
In total, 330 patients with sporadic acoustic neuromas who were treated with LINAC SRS between March 2006 and March 2020 were retrospectively evaluated to assess their initial tumor enlargement. The tumors were divided into homogeneously enhanced, heterogeneously enhanced, and cystic types based on the morphological characteristics noted on magnetic resonance images. Tumor control was assessed in 275 patients with a follow-up duration of more than 2 years.RESULTS:
Initial enlargement was observed in 137 of 330 (41.5%) tumors as early as 3 months after LINAC SRS. Data analysis revealed that postoperative tumors with a residual volume lower than 2.5â¯cm3 had a lower incidence of initial enlargement (pâ¯= 0.039). No correlation was noted between the initial enlargement and morphological characteristics of tumors. In patients with a mean follow-up duration of 82.8⯱ 37.2 months, heterogeneously enhanced tumors exhibited a lower control rate than homogeneously enhanced and cystic tumors (pâ¯= 0.045). No correlation was noted between initial enlargement and tumor control.CONCLUSION:
Initial enlargement can occur as early as 3 months after SRS. Postoperative residual tumors with a volume lower than 2.5â¯cm3 exhibit a lower incidence of initial enlargement. Heterogeneously enhanced tumors have a lower local control rate.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neuroma Acústico
/
Radiocirurgia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Strahlenther Onkol
Assunto da revista:
NEOPLASIAS
/
RADIOTERAPIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Taiwan