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Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial.
Chastre, Jean; François, Bruno; Bourgeois, Marc; Komnos, Apostolos; Ferrer, Ricard; Rahav, Galia; De Schryver, Nicolas; Lepape, Alain; Koksal, Iftihar; Luyt, Charles-Edouard; Sánchez-García, Miguel; Torres, Antoni; Eggimann, Philippe; Koulenti, Despoina; Holland, Thomas L; Ali, Omar; Shoemaker, Kathryn; Ren, Pin; Sauser, Julien; Ruzin, Alexey; Tabor, David E; Akhgar, Ahmad; Wu, Yuling; Jiang, Yu; DiGiandomenico, Antonio; Colbert, Susan; Vandamme, Drieke; Coenjaerts, Frank; Malhotra-Kumar, Surbhi; Timbermont, Leen; Oliver, Antonio; Barraud, Olivier; Bellamy, Terramika; Bonten, Marc; Goossens, Herman; Reisner, Colin; Esser, Mark T; Jafri, Hasan S.
Afiliação
  • Chastre J; Service de Médecine Intensive Réanimation, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University, 47-83 Bd de l'Hôpital, 75651, Paris, France. jean.chastre@gmail.com.
  • François B; Réanimation Polyvalente and Inserm CIC 1435 & UMR 1092, CHU, Limoges, France.
  • Bourgeois M; AZ Sint-Jan Brugge-Oostende AV, Brugge, Belgium.
  • Komnos A; General Hospital of Larissa, Larissa, Greece.
  • Ferrer R; SODIR-VHIR Research Group, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
  • Rahav G; Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • De Schryver N; Clinique Saint-Pierre, Ottignies, Belgium.
  • Lepape A; Hospices Civils de Lyon Hôpital Lyon Sud, Lyon, France.
  • Koksal I; Faculty of Medicine, Trabzon and Acibadem University Faculty of Medicine, Karadeniz Technical University, Istanbul, Turkey.
  • Luyt CE; Service de Médecine Intensive Réanimation, Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Sorbonne University, 47-83 Bd de l'Hôpital, 75651, Paris, France.
  • Sánchez-García M; Critical Care Department, Hospital Clínico San Carlos, Universidad Complutense, Madrid, Spain.
  • Torres A; Servei de Pneumologia, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, ICREA, Barcelona, Spain.
  • Eggimann P; Department of Locomotor Apparatus, Centre Hospitalier Universitaire Vaudois CHUV, Lausanne, Switzerland.
  • Koulenti D; The University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
  • Holland TL; 2nd Critical Care Department, Attikon University Hospital, National and Kapodistrian, University of Athens, Athens, Greece.
  • Ali O; Duke Clinical Research Institute, Durham, NC, USA.
  • Shoemaker K; Clinical Research and Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca Biopharmaceuticals, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Ren P; Clinical Research and Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca Biopharmaceuticals, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Sauser J; Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Ruzin A; Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Tabor DE; Infection Control Program, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland.
  • Akhgar A; Clinical Research and Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca Biopharmaceuticals, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Wu Y; Clinical Research and Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca Biopharmaceuticals, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Jiang Y; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • DiGiandomenico A; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Colbert S; Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.
  • Vandamme D; Clinical Research and Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca Biopharmaceuticals, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Coenjaerts F; Oncology, US SM&M, AstraZeneca, Wilmington, NC, USA.
  • Malhotra-Kumar S; Inserm CIC 1435, CHU, Limoges, France.
  • Timbermont L; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Oliver A; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
  • Barraud O; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
  • Bellamy T; Servicio de Microbiología y Unidad de Investigación, Hospital Universitari Son Espases, Institut d'Investigació Sanitaria Illes Balears, Palma, Spain.
  • Bonten M; INSERM U1092, Centre Hospitalier Universitaire de Limoges, Université Limoges, Limoges, France.
  • Goossens H; Clinical Research and Development, Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca Biopharmaceuticals, One MedImmune Way, Gaithersburg, MD, 20878, USA.
  • Reisner C; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Esser MT; Julius Center for Health Science and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  • Jafri HS; Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.
Crit Care ; 26(1): 355, 2022 11 15.
Article em En | MEDLINE | ID: mdl-36380312
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Pseudomonas / Pneumonia Associada à Ventilação Mecânica Tipo de estudo: Clinical_trials / Etiology_studies Limite: Adolescent / Animals / Humans Idioma: En Revista: Crit Care Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Pseudomonas / Pneumonia Associada à Ventilação Mecânica Tipo de estudo: Clinical_trials / Etiology_studies Limite: Adolescent / Animals / Humans Idioma: En Revista: Crit Care Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França