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Challenges in glioblastoma research: focus on the tumor microenvironment.
Bikfalvi, Andreas; da Costa, Cristine Alves; Avril, Tony; Barnier, Jean-Vianney; Bauchet, Luc; Brisson, Lucie; Cartron, Pierre Francois; Castel, Hélène; Chevet, Eric; Chneiweiss, Hervé; Clavreul, Anne; Constantin, Bruno; Coronas, Valérie; Daubon, Thomas; Dontenwill, Monique; Ducray, Francois; Enz-Werle, Natacha; Figarella-Branger, Dominique; Fournier, Isabelle; Frenel, Jean-Sébastien; Gabut, Mathieu; Galli, Thierry; Gavard, Julie; Huberfeld, Gilles; Hugnot, Jean-Philippe; Idbaih, Ahmed; Junier, Marie-Pierre; Mathivet, Thomas; Menei, Philippe; Meyronet, David; Mirjolet, Céline; Morin, Fabrice; Mosser, Jean; Moyal, Elisabeth Cohen-Jonathan; Rousseau, Véronique; Salzet, Michel; Sanson, Marc; Seano, Giorgio; Tabouret, Emeline; Tchoghandjian, Aurélie; Turchi, Laurent; Vallette, Francois M; Vats, Somya; Verreault, Maité; Virolle, Thierry.
Afiliação
  • Bikfalvi A; Bordeaux University, INSERM, U1312 BRIC, Tumor and Vascular Biology Laboratory, F-33600, Pessac, France. Electronic address: andreas.bikfalvi@u-bordeaux.fr.
  • da Costa CA; Côte d'Azur University, INSERM, CNRS, Institut de Pharmacologie Moléculaire et Cellulaire, Team "Laboratory of Excellence (LABEX) Distalz", F-06560 Nice, France.
  • Avril T; Rennes University, Inserm U1242, Centre de Lutte contre le Cancer Eugène Marquis, F- 35000 Rennes, France.
  • Barnier JV; Institute of Neuroscience Paris-Saclay, UMR9197, CNRS, Univ. Paris-Saclay, F-91191 Gif-sur-Yvette, France.
  • Bauchet L; Montpellier University Medical Center, Department of Neurosurgery, INSERM U1191, F-34090 Montpellier, France.
  • Brisson L; Bordeaux University, INSERM, U1312 BRIC, Tumor and Vascular Biology Laboratory, F-33600, Pessac, France.
  • Cartron PF; CRCI2NA, INSERM U1307, CNRS UMR6075, Nantes Universite, 44007 Nantes, France.
  • Castel H; Normandie University, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), F-76000 Rouen, France.
  • Chevet E; Rennes University, Inserm U1242, Centre de Lutte contre le Cancer Eugène Marquis, F- 35000 Rennes, France.
  • Chneiweiss H; Sorbonne University, CNRS UMR8246, Inserm U1130, IBPS-Neuroscience Paris Seine, F- 75005 Paris, France.
  • Clavreul A; Angers University, CHU d'Angers, CRCINA, F-49000 Angers, France.
  • Constantin B; Poitiers University, CNRS UMR 6041, Laboratory Channels & Connexins in Cancers and Cell Stemness, F-86000 Poitiers, France.
  • Coronas V; Poitiers University, CNRS UMR 6041, Laboratory Channels & Connexins in Cancers and Cell Stemness, F-86000 Poitiers, France.
  • Daubon T; Bordeaux University, CNRS, IBGC, UMR 5095, F-33 077 Bordeaux, France.
  • Dontenwill M; Strasbourg University, Laboratoire de Bioimagerie et Pathologie, UMR7021 CNRS, F-67401 Illkirch-Graffenstaden, France.
  • Ducray F; Lyon I University, Cancer Research Centre of Lyon (CRCL) INSERM 1052&CNRS UMR5286, Centre Léon Bérard, Lyon 69008, France., F-69622 Villeurbanne, France.
  • Enz-Werle N; Strasbourg University, Laboratoire de Bioimagerie et Pathologie, UMR7021 CNRS, F-67401 Illkirch-Graffenstaden, France.
  • Figarella-Branger D; Aix-Marseille University, Service d'Anatomie Pathologique et de Neuropathologie, Hôpital de la Timone, F-13385 Marseille, France.
  • Fournier I; Lille University, Inserm, CHU Lille, U1192, Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM), F-59000 Lille, France.
  • Frenel JS; Normandie University, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), F-76000 Rouen, France.
  • Gabut M; Lyon I University, Cancer Research Centre of Lyon (CRCL) INSERM 1052&CNRS UMR5286, Centre Léon Bérard, Lyon 69008, France., F-69622 Villeurbanne, France.
  • Galli T; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, GHU PARIS Psychiatrie & Neurosciences, F-75014 Paris, France.
  • Gavard J; CRCI2NA, INSERM U1307, CNRS UMR6075, Nantes Universite, 44007 Nantes, France.
  • Huberfeld G; College de France, Center for Interdisciplinary Research in Biology (CIRB), CNRS, INSERM, Université PSL, Paris 75005, France.
  • Hugnot JP; Montpellier University, Institut de Génomique Fonctionnelle, CNRS, INSERM, F-34094 Montpellier, France.
  • Idbaih A; Sorbonne University, AP-HP, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, F-75013, Paris, France.
  • Junier MP; Sorbonne University, CNRS UMR8246, Inserm U1130, IBPS-Neuroscience Paris Seine, F- 75005 Paris, France.
  • Mathivet T; Bordeaux University, INSERM, U1312 BRIC, Tumor and Vascular Biology Laboratory, F-33600, Pessac, France.
  • Menei P; Angers University, CHU d'Angers, CRCINA, F-49000 Angers, France.
  • Meyronet D; Institute of Neuropathology, Hospices Civils de Lyon, F-69008, Lyon, France.
  • Mirjolet C; Centre Georges-François Leclerc, UNICANCER, Dijon, France. Inserm U1231, Equipe Cadir, F-21000 Dijon, France.
  • Morin F; Normandie University, INSERM U1239, DC2N, Institute for Research and Innovation in Biomedicine (IRIB), F-76000 Rouen, France.
  • Mosser J; Rennes University, Inserm U1242, Centre de Lutte contre le Cancer Eugène Marquis, F- 35000 Rennes, France.
  • Moyal EC; Institut Claudius Regaud, NSERM 1037, CRCT Team RADOPT, Département de Radiothérapie, IUCT-Oncopole, F-31100 Toulouse, France.
  • Rousseau V; Institute of Neuroscience Paris-Saclay, UMR9197, CNRS, Univ. Paris-Saclay, F-91191 Gif-sur-Yvette, France.
  • Salzet M; Lille University, Inserm, CHU Lille, U1192, Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse (PRISM), F-59000 Lille, France.
  • Sanson M; Sorbonne University, AP-HP, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, F-75013, Paris, France.
  • Seano G; Curie Institute Research Center, Tumor Microenvironment Laboratory, PSL Research University, Inserm U1021, CNRS UMR3347, F-91898 Orsay, France.
  • Tabouret E; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, F-13005 Marseille, France.
  • Tchoghandjian A; Aix-Marseille University, CNRS, INP, Inst Neurophysiopathol, F-13005 Marseille, France.
  • Turchi L; Côte D'Azur University, CNRS, INSERM, Institut de Biologie Valrose, Team INSERM "Cancer Stem Cell Plasticity and Functional Intra-tumor Heterogeneity", F-06108 Nice, France.
  • Vallette FM; CRCI2NA, INSERM U1307, CNRS UMR6075, Nantes Universite, 44007 Nantes, France.
  • Vats S; Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Membrane Traffic in Healthy & Diseased Brain, GHU PARIS Psychiatrie & Neurosciences, F-75014 Paris, France.
  • Verreault M; Sorbonne University, AP-HP, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, F-75013, Paris, France.
  • Virolle T; Côte D'Azur University, CNRS, INSERM, Institut de Biologie Valrose, Team INSERM "Cancer Stem Cell Plasticity and Functional Intra-tumor Heterogeneity", F-06108 Nice, France.
Trends Cancer ; 9(1): 9-27, 2023 01.
Article em En | MEDLINE | ID: mdl-36400694
ABSTRACT
Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has been recognized as an important player and therapeutic target in GBM. However, there is a need for a full and integrated understanding of the different cellular and molecular components involved in the GBM TME and their interactions for the development of more efficient therapies. In this review, we provide a comprehensive report of the GBM TME, which assembles the contributions of physicians and translational researchers working on brain tumor pathology and therapy in France. We propose a holistic view of the subject by delineating the specific features of the GBM TME at the cellular, molecular, and therapeutic levels.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Limite: Humans Idioma: En Revista: Trends Cancer Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Limite: Humans Idioma: En Revista: Trends Cancer Ano de publicação: 2023 Tipo de documento: Article