Distinction of early complement classical and lectin pathway activation <i>via</i> quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.

Hurler, Lisa; Toonen, Erik J M; Kajdácsi, Erika; van Bree, Bregje; Brandwijk, Ricardo J M G E; de Bruin, Wieke; Lyons, Paul A; Bergamaschi, Laura; Sinkovits, György; Cervenak, László; Würzner, Reinhard; Prohászka, Zoltán

Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.

Hurler, Lisa; Toonen, Erik J M; Kajdácsi, Erika; van Bree, Bregje; Brandwijk, Ricardo J M G E; de Bruin, Wieke; Lyons, Paul A; Bergamaschi, Laura; Sinkovits, György; Cervenak, László; Würzner, Reinhard; Prohászka, Zoltán.

Afiliação

Hurler L; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Toonen EJM; Research and Development Department, Hycult Biotech, Uden, Netherlands.
Kajdácsi E; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
van Bree B; Research and Development Department, Hycult Biotech, Uden, Netherlands.
Brandwijk RJMGE; Research and Development Department, Hycult Biotech, Uden, Netherlands.
de Bruin W; Research and Development Department, Hycult Biotech, Uden, Netherlands.
Lyons PA; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, United Kingdom.
Bergamaschi L; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Sinkovits G; Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom.
Würzner R; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.
Prohászka Z; Department of Internal Medicine and Haematology, Semmelweis University, Budapest, Hungary.

Front Immunol ; 13: 1039765, 2022.

Article em En | MEDLINE | ID: mdl-36420270

Assuntos

COVID-19; Serina Proteases Associadas a Proteína de Ligação a Manose; Adulto; Humanos; Proteína Inibidora do Complemento C1; Proteínas do Sistema Complemento; COVID-19/diagnóstico; Lectinas; Serina Proteases Associadas a Proteína de Ligação a Manose/metabolismo; Ensaio de Imunoadsorção Enzimática

Palavras-chave

C1-INH complexes; C1s/C1-INH complex; MASP-1/C1-INH complex; assay development and validation; classical pathway activation; early complement activation; lectin pathway activation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serina Proteases Associadas a Proteína de Ligação a Manose / COVID-19 Tipo de estudo: Diagnostic_studies Limite: Adult / Humans Idioma: En Revista: Front Immunol Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Hungria

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