A Positively Selected <i>fur</i>-R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression.

Loh, John T; Struttmann, Emily L; Favret, Natalie; Harvey, M Lorena; Pakala, Suman B; Chopra, Abha; McClain, Mark S; Cover, Timothy L

A Positively Selected fur-R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression.

Loh, John T; Struttmann, Emily L; Favret, Natalie; Harvey, M Lorena; Pakala, Suman B; Chopra, Abha; McClain, Mark S; Cover, Timothy L.

Afiliação

Loh JT; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Struttmann EL; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Favret N; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Harvey ML; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Pakala SB; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Chopra A; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia.
McClain MS; Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Cover TL; Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Infect Immun ; 91(2): e0042022, 2023 02 16.

Article em En | MEDLINE | ID: mdl-36633416

Assuntos

Proteínas de Bactérias; Helicobacter pylori; Proteínas Repressoras; Humanos; Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Regulação Bacteriana da Expressão Gênica; Infecções por Helicobacter; Helicobacter pylori/genética; Helicobacter pylori/fisiologia; Mutação; Cloreto de Sódio/metabolismo; Proteínas Repressoras/genética; Proteínas Repressoras/metabolismo

Palavras-chave

evolution; evolutionary biology; fitness; gene regulation; positive selection; transcriptional regulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas de Bactérias / Helicobacter pylori Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Infect Immun Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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