Antiviral Approaches against Influenza Virus.
Clin Microbiol Rev
; 36(1): e0004022, 2023 03 23.
Article
em En
| MEDLINE
| ID: mdl-36645300
ABSTRACT
Preventing and controlling influenza virus infection remains a global public health challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are responsible for high morbidity, mortality, and substantial economic impact. Vaccines are the prophylaxis mainstay in the fight against influenza. However, vaccination fails to confer complete protection due to inadequate vaccination coverages, vaccine shortages, and mismatches with circulating strains. Antivirals represent an important prophylactic and therapeutic measure to reduce influenza-associated morbidity and mortality, particularly in high-risk populations. Here, we review current FDA-approved influenza antivirals with their mechanisms of action, and different viral- and host-directed influenza antiviral approaches, including immunomodulatory interventions in clinical development. Furthermore, we also illustrate the potential utility of machine learning in developing next-generation antivirals against influenza.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Orthomyxoviridae
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Vacinas contra Influenza
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Infecções por Orthomyxoviridae
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Influenza Humana
Limite:
Humans
Idioma:
En
Revista:
Clin Microbiol Rev
Assunto da revista:
MICROBIOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos