Paired optogenetic and visual stimulation can change the orientation selectivity of visual cortex neurons.
Biochem Biophys Res Commun
; 646: 63-69, 2023 02 26.
Article
em En
| MEDLINE
| ID: mdl-36706707
ABSTRACT
Synaptic plasticity is currently considered the main mechanism underlying the plastic modification of neural networks. The vast majority of studies of synaptic plasticity are carried out on reduced preparations, but the situation in vivo is fundamentally different from that in vitro. In this work, we used the Hebbian paradigm, which is known to induce long-term changes in synaptic strength in vitro, to manipulate the properties of a single pyramidal neuron in the mouse visual cortex. We have shown that optogenetic stimulation of a ChR2-expressing pyramidal neuron in the primary visual cortex of Thy-ChR2 mice paired with the presentation of a visual stimulus of non-optimal orientation induces long-term changes in the properties of the receptive field, manifested in alteration of the orientation selectivity of the cell. Non-paired stimulation did not lead to changes in the properties of the receptive field of the neuron during the experiment. Thus, we have demonstrated the role of associative plasticity in the dynamic organization of the receptive fields of neurons in the visual cortex.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Córtex Visual
/
Optogenética
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Federação Russa