Quantitative Characterization of Clinically Relevant Drug-Metabolizing Enzymes and Transporters in Rat Liver and Intestinal Segments for Applications in PBPK Modeling.

Sharma, Sheena; Singh, Dilip K; Mettu, Vijay S; Yue, Guihua; Ahire, Deepak; Basit, Abdul; Heyward, Scott; Prasad, Bhagwat

Sharma, Sheena; Singh, Dilip K; Mettu, Vijay S; Yue, Guihua; Ahire, Deepak; Basit, Abdul; Heyward, Scott; Prasad, Bhagwat.

Afiliação

Sharma S; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Singh DK; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Mettu VS; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Yue G; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Ahire D; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Basit A; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.
Heyward S; BioIVT, Baltimore, Maryland 21227, United States.
Prasad B; College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington 99202, United States.

Mol Pharm ; 20(3): 1737-1749, 2023 03 06.

Article em En | MEDLINE | ID: mdl-36791335

Assuntos

Proteínas de Membrana Transportadoras; Proteínas de Neoplasias; Humanos; Ratos; Animais; Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/metabolismo; Ratos Sprague-Dawley; Proteínas de Neoplasias/metabolismo; Proteínas de Membrana Transportadoras/metabolismo; Fígado/metabolismo; Intestinos; Digoxina/metabolismo

Palavras-chave

PBPK modeling; digoxin; drug metabolism; drug transport; interspecies differences; quantitative proteomics; total protein approach

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Proteínas de Neoplasias Tipo de estudo: Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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