Patient-Reported Outcomes in Young Adults with Myeloproliferative Neoplasms.
Acta Haematol
; 146(4): 293-306, 2023.
Article
em En
| MEDLINE
| ID: mdl-36812897
ABSTRACT
INTRODUCTION:
Genetic landscape, disease characteristics, and clinical outcomes of young adults with myeloproliferative neoplasms (MPNs) were reported. However, data on patient-reported outcomes (PROs) in young adults with MPNs were rare.METHODS:
We conducted a multicenter, cross-sectional study to compare the PROs in respondents with thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF) by age at survey, including the young group (18-40 years), middle-aged group (41-60 years), and elderly group (>60 years).RESULTS:
Of the 1,664 respondents with MPNs, 349 (21.0%) were young including 244 (69.9%) with ET, 34 (9.7%) with PV, and 71 (20.3%) with MF. In multivariate analyses, the young groups with ET and MF were associated with the lowest MPN-10 scores among the 3 age groups; those with MF, highest proportion of reporting negative impact of disease and therapy on their daily life and work. The young groups with MPNs had the highest physical component summary scores but the lowest mental component summary scores in those with ET. The young groups with MPNs were most concerned about fertility; those with ET, treatment-related adverse events and long-term efficacy of treatment.CONCLUSIONS:
We concluded that young adults with MPNs have different PROs compared with middle-aged and elderly patients.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Policitemia Vera
/
Mielofibrose Primária
/
Transtornos Mieloproliferativos
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
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Humans
/
Middle aged
Idioma:
En
Revista:
Acta Haematol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China