Biochemical and biophysical characterization of the nucleic acid binding properties of the RNA/DNA binding protein EWS.

Selig, Emily E; Bhura, Roohi; White, Matthew R; Akula, Shivani; Hoffman, Renee D; Tovar, Carmel N; Xu, Xiaoping; Booth, Rachell E; Libich, David S

Selig, Emily E; Bhura, Roohi; White, Matthew R; Akula, Shivani; Hoffman, Renee D; Tovar, Carmel N; Xu, Xiaoping; Booth, Rachell E; Libich, David S.

Afiliação

Selig EE; Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA.
Bhura R; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA.
White MR; Department of Chemistry and Biochemistry, University of the Incarnate Word, San Antonio, Texas, 78209, USA.
Akula S; Department of Chemistry and Biochemistry, University of the Incarnate Word, San Antonio, Texas, 78209, USA.
Hoffman RD; Department of Chemistry and Biochemistry, University of the Incarnate Word, San Antonio, Texas, 78209, USA.
Tovar CN; Department of Chemistry and Biochemistry, University of the Incarnate Word, San Antonio, Texas, 78209, USA.
Xu X; Department of Chemistry and Biochemistry, University of the Incarnate Word, San Antonio, Texas, 78209, USA.
Booth RE; Greehey Children's Cancer Research Institute, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA.
Libich DS; Department of Biochemistry and Structural Biology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, 78229, USA.

Biopolymers ; 114(5): e23536, 2023 May.

Article em En | MEDLINE | ID: mdl-36929870

Assuntos

Ácidos Nucleicos; Proteínas de Ligação a RNA; Humanos; Criança; Proteína EWS de Ligação a RNA/genética; Proteína EWS de Ligação a RNA/química; Proteína EWS de Ligação a RNA/metabolismo; Proteínas de Ligação a DNA; DNA; RNA; Linhagem Celular Tumoral

Palavras-chave

EWS; G-quadruplex; NMR; R-loop; intrinsically disordered protein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Nucleicos / Proteínas de Ligação a RNA Limite: Child / Humans Idioma: En Revista: Biopolymers Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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