Exacerbated Neuropathy in POLAR A and M Trials Due to Redox Interaction of PledOx-Associated Mn<sup>2+</sup> and Oxaliplatin-Associated Pt<sup>2</sup>.

Karlsson, Jan Olof G; Jynge, Per; Ignarro, Louis J

Exacerbated Neuropathy in POLAR A and M Trials Due to Redox Interaction of PledOx-Associated Mn²⁺ and Oxaliplatin-Associated Pt².

Karlsson, Jan Olof G; Jynge, Per; Ignarro, Louis J.

Afiliação

Karlsson JOG; Department of Biomedical and Clinical Sciences, Division of Clinical Chemistry and Pharmacology, Linköping University, 581 83 Linköping, Sweden.
Jynge P; Department of Radiology, Innlandet Trust Hospital, Gjøvik Hospital, 2819 Gjøvik, Norway.
Ignarro LJ; Department of Pharmacology, UCLA School of Medicine, 264 El Camino Drive, Beverly Hills, CA 90212, USA.

Antioxidants (Basel) ; 12(3)2023 Mar 01.

Article em En | MEDLINE | ID: mdl-36978857

Palavras-chave

POLAR A and M trials; calmangafodipir (PledOx); chemotherapy-induced peripheral neuropathy; clinical phase III trials; drug interaction; manganese; oxaliplatin; platinum; redox active cations

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Risk_factors_studies Idioma: En Revista: Antioxidants (Basel) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia

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