Metformin Suppresses Thioacetamide-Induced Chronic Kidney Disease in Association with the Upregulation of AMPK and Downregulation of Oxidative Stress and Inflammation as Well as Dyslipidemia and Hypertension.

Alshahrani, Mohammad Y; Ebrahim, Hasnaa A; Alqahtani, Saeed M; Bayoumy, Nervana M; Kamar, Samaa S; ShamsEldeen, Asmaa M; Haidara, Mohamed A; Al-Ani, Bahjat; Albawardi, Alia

Alshahrani, Mohammad Y; Ebrahim, Hasnaa A; Alqahtani, Saeed M; Bayoumy, Nervana M; Kamar, Samaa S; ShamsEldeen, Asmaa M; Haidara, Mohamed A; Al-Ani, Bahjat; Albawardi, Alia.

Afiliação

Alshahrani MY; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha 61413, Saudi Arabia.
Ebrahim HA; Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Alqahtani SM; Department of Surgery, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia.
Bayoumy NM; Department of Physiology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Kamar SS; Department of Histology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo 11566, Egypt.
ShamsEldeen AM; Histology Department, Armed Forces College of Medicine, Cairo 11566, Egypt.
Haidara MA; Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo 11566, Egypt.
Al-Ani B; Department of Physiology, Kasr Al-Aini Faculty of Medicine, Cairo University, Cairo 11566, Egypt.
Albawardi A; Department of Physiology, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia.

Molecules ; 28(6)2023 Mar 18.

Article em En | MEDLINE | ID: mdl-36985728

Assuntos

Dislipidemias; Hipertensão; Metformina; Insuficiência Renal Crônica; Ratos; Animais; Metformina/farmacologia; Metformina/uso terapêutico; Proteínas Quinases Ativadas por AMP/metabolismo; Tioacetamida/toxicidade; Inibidor Tecidual de Metaloproteinase-1/metabolismo; Regulação para Cima; Regulação para Baixo; Estresse Oxidativo; Inflamação/metabolismo; Insuficiência Renal Crônica/metabolismo; Fibrose; Hipertensão/induzido quimicamente; Hipertensão/tratamento farmacológico; Hipertensão/metabolismo; Dislipidemias/induzido quimicamente; Dislipidemias/tratamento farmacológico; Dislipidemias/metabolismo; Fígado/metabolismo; Cirrose Hepática/tratamento farmacológico

Palavras-chave

AMPK; TIMP-1; chronic kidney disease; dyslipidemia; hypertension; inflammation; metformin; oxidative stress; renal fibrosis; thioacetamide

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Insuficiência Renal Crônica / Dislipidemias / Hipertensão / Metformina Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Arábia Saudita

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