The case for the therapeutic use of mechanistic/mammalian target of rapamycin (mTOR) inhibitors in xenotransplantation.

Maenaka, Akihiro; Kinoshita, Kohei; Hara, Hidetaka; Cooper, David K C

Maenaka, Akihiro; Kinoshita, Kohei; Hara, Hidetaka; Cooper, David K C.

Afiliação

Maenaka A; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Kinoshita K; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.
Hara H; College of Veterinary Medicine, Yunnan Agricultural University, Kunming, Yunnan, China.
Cooper DKC; Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA.

Xenotransplantation ; 30(3): e12802, 2023.

Article em En | MEDLINE | ID: mdl-37029499

Assuntos

Imunossupressores; Sirolimo; Animais; Suínos; Sirolimo/farmacologia; Sirolimo/uso terapêutico; Transplante Heterólogo; Imunossupressores/farmacologia; Imunossupressores/uso terapêutico; Serina-Treonina Quinases TOR; Linfócitos T Reguladores; Mamíferos

Palavras-chave

Tregs; graft growth; immunosuppression; inflammation; mTOR inhibitor; neoplasia; viral infection; xenotransplantation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sirolimo / Imunossupressores Limite: Animals Idioma: En Revista: Xenotransplantation Assunto da revista: TRANSPLANTE Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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