Regioselective oxidation of heterocyclic aromatic hydrocarbons catalyzed by cytochrome P450: A case study of carbazole.

Hou, Zexi; Li, Yanwei; Zheng, Mingna; Liu, Xinning; Zhang, Qingzhu; Wang, Wenxing

Hou, Zexi; Li, Yanwei; Zheng, Mingna; Liu, Xinning; Zhang, Qingzhu; Wang, Wenxing.

Afiliação

Hou Z; Environment Research Institute, Shandong University, Qingdao 266237, PR China.
Li Y; Environment Research Institute, Shandong University, Qingdao 266237, PR China; Shenzhen Research Institute, Shandong University, Shenzhen 518057, PR China. Electronic address: lyw@sdu.edu.cn.
Zheng M; Environment Research Institute, Shandong University, Qingdao 266237, PR China.
Liu X; Environment Research Institute, Shandong University, Qingdao 266237, PR China.
Zhang Q; Environment Research Institute, Shandong University, Qingdao 266237, PR China.
Wang W; Environment Research Institute, Shandong University, Qingdao 266237, PR China.

Ecotoxicol Environ Saf ; 258: 114964, 2023 Jun 15.

Article em En | MEDLINE | ID: mdl-37121081

Assuntos

Hidrocarbonetos Aromáticos; Hidrocarbonetos Policíclicos Aromáticos; Humanos; Citocromo P-450 CYP1A1/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Carbazóis; Hidrocarbonetos Policíclicos Aromáticos/metabolismo; Hidrogênio; Catálise; Hidroxilação

Palavras-chave

Activation; CYP1A1; Cytochrome P450 enzyme; Density functional theory; Metabolism; Quantum mechanics/molecular mechanics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrocarbonetos Policíclicos Aromáticos / Hidrocarbonetos Aromáticos Limite: Humans Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2023 Tipo de documento: Article

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