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Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38.
Armstrong, Jane F; Campo, Brice; Alexander, Stephen P H; Arendse, Lauren B; Cheng, Xiu; Davenport, Anthony P; Faccenda, Elena; Fidock, David A; Godinez-Macias, Karla P; Harding, Simon D; Kato, Nobutaka; Lee, Marcus C S; Luth, Madeline R; Mazitschek, Ralph; Mittal, Nimisha; Niles, Jacquin C; Okombo, John; Ottilie, Sabine; Pasaje, Charisse Flerida A; Probst, Alexandra S; Rawat, Mukul; Rocamora, Frances; Sakata-Kato, Tomoyo; Southan, Christopher; Spedding, Michael; Tye, Mark A; Yang, Tuo; Zhao, Na; Davies, Jamie A.
Afiliação
  • Armstrong JF; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK.
  • Campo B; Medicines for Malaria Venture, Geneva, Switzerland.
  • Alexander SPH; School of Life Sciences, University of Nottingham Medical School, Nottingham, UK.
  • Arendse LB; Drug Discovery and Development Centre (H3D), South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
  • Cheng X; Global Health Drug Discovery Institute, Beijing, China.
  • Davenport AP; Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK.
  • Faccenda E; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK.
  • Fidock DA; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
  • Godinez-Macias KP; Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, USA.
  • Harding SD; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego (UCSD), La Jolla, California, USA.
  • Kato N; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK.
  • Lee MCS; Global Health Drug Discovery Institute, Beijing, China.
  • Luth MR; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.
  • Mazitschek R; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA.
  • Mittal N; Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Niles JC; Thermo Fisher Scientific, San Diego, California, USA.
  • Okombo J; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Ottilie S; Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.
  • Pasaje CFA; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA.
  • Probst AS; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
  • Rawat M; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA.
  • Rocamora F; Parasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.
  • Sakata-Kato T; Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California, USA.
  • Southan C; Global Health Drug Discovery Institute, Beijing, China.
  • Spedding M; Deanery of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK.
  • Tye MA; Spedding Research Solutions SAS, Le Vésinet, France.
  • Yang T; Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Zhao N; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California, USA.
  • Davies JA; Global Health Drug Discovery Institute, Beijing, China.
Br J Pharmacol ; 180(15): 1899-1929, 2023 08.
Article em En | MEDLINE | ID: mdl-37197802
ABSTRACT
Antimalarial drug discovery has until recently been driven by high-throughput phenotypic cellular screening, allowing millions of compounds to be assayed and delivering clinical drug candidates. In this review, we will focus on target-based approaches, describing recent advances in our understanding of druggable targets in the malaria parasite. Targeting multiple stages of the Plasmodium lifecycle, rather than just the clinically symptomatic asexual blood stage, has become a requirement for new antimalarial medicines, and we link pharmacological data clearly to the parasite stages to which it applies. Finally, we highlight the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, a web resource developed for the malaria research community that provides open and optimized access to published data on malaria pharmacology.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Malária / Antimaláricos Limite: Humans Idioma: En Revista: Br J Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Malária / Antimaláricos Limite: Humans Idioma: En Revista: Br J Pharmacol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido