Gemcitabine-loaded synthetic high-density lipoprotein preferentially eradicates hepatic monocyte-derived macrophages in mouse liver with colorectal cancer metastases.

Xiong, Feng-Qin; Zhang, Wen; Zheng, Chao; Li, Yu; Gong, Xiang; Zhang, Yuan; Wang, Hao; Zhang, Peng-Cheng; Li, Ya-Ping

Xiong, Feng-Qin; Zhang, Wen; Zheng, Chao; Li, Yu; Gong, Xiang; Zhang, Yuan; Wang, Hao; Zhang, Peng-Cheng; Li, Ya-Ping.

Afiliação

Xiong FQ; China State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Zhang W; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Zheng C; China State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Li Y; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Gong X; China State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Zhang Y; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Wang H; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Zhang PC; China State Institute of Pharmaceutical Industry, Shanghai, 201203, China.
Li YP; State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

Acta Pharmacol Sin ; 44(11): 2331-2341, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37225846

Assuntos

Neoplasias Colorretais; Neoplasias Hepáticas; Camundongos; Animais; Gencitabina; Linfócitos T CD8-Positivos/metabolismo; Lipoproteínas HDL; Neoplasias Hepáticas/tratamento farmacológico; Neoplasias Hepáticas/metabolismo; Neoplasias Colorretais/tratamento farmacológico; Macrófagos/metabolismo; Antígenos de Neoplasias; Microambiente Tumoral; Linhagem Celular Tumoral

Palavras-chave

colorectal cancer; gemcitabine; liver metastasis; macrophages; synthetic high-density lipoprotein

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Neoplasias Hepáticas Limite: Animals Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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