Mutations in the Vicinity of the IRAK3 Guanylate Cyclase Center Impact Its Subcellular Localization and Ability to Modulate Inflammatory Signaling in Immortalized Cell Lines.

Turek, Ilona; Nguyen, Trang H; Galea, Charles; Abad, Isaiah; Freihat, Lubna; Manallack, David T; Velkov, Tony; Irving, Helen

Turek, Ilona; Nguyen, Trang H; Galea, Charles; Abad, Isaiah; Freihat, Lubna; Manallack, David T; Velkov, Tony; Irving, Helen.

Afiliação

Turek I; Department of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Bendigo, VIC 3552, Australia.
Nguyen TH; La Trobe Institute for Molecular Science, La Trobe University, Bendigo, VIC 3552, Australia.
Galea C; Department of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Bendigo, VIC 3552, Australia.
Abad I; La Trobe Institute for Molecular Science, La Trobe University, Bendigo, VIC 3552, Australia.
Freihat L; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.
Manallack DT; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.
Velkov T; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.
Irving H; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC 3052, Australia.

Int J Mol Sci ; 24(10)2023 May 10.

Article em En | MEDLINE | ID: mdl-37239919

Assuntos

Guanilato Ciclase; Quinases Associadas a Receptores de Interleucina-1; Humanos; Guanilato Ciclase/metabolismo; Quinases Associadas a Receptores de Interleucina-1/genética; Quinases Associadas a Receptores de Interleucina-1/metabolismo; Lipopolissacarídeos/farmacologia; Células HEK293; Mutação; NF-kappa B/genética

Palavras-chave

cyclic guanosine monophosphate (cGMP); guanylate cyclase; human Toll-like receptor 4 (hTLR4); inflammatory cytokines; interleukin-1 receptor-associated kinase 3 (IRAK3 or IRAK-M); lipopolysaccharide; nuclear factor kappa-light-chain-enhancer of activated B (NFκB)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases Associadas a Receptores de Interleucina-1 / Guanilato Ciclase Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Austrália

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