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Characterization of Divergent Metabolic Pathways in Elucidating an Unexpected, Slow-Forming, and Long Half-Life Major Metabolite of Iclepertin.
Chan, Tom S; Byer-Alcorace, Alexander J; Latli, Bachir; Liu, Pingrong; Maw, Hlaing H; Raymond, Klairynne G; Scaringella, Young-Sun; Teitelbaum, Aaron M; Wang, Ting; Whitcher-Johnstone, Andrea; Taub, Mitchell E.
Afiliação
  • Chan TS; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA. tom.chan@boehringer-ingelheim.com.
  • Byer-Alcorace AJ; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Latli B; Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Liu P; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Maw HH; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Raymond KG; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Scaringella YS; Department of Biotherapeutics Discovery, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Teitelbaum AM; Department of Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
  • Wang T; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Whitcher-Johnstone A; Department of Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Rd., Ridgefield, CT, 06877, USA.
  • Taub ME; DMPK Oncology, AstraZeneca Inc., 35 Gatehouse Dr., Waltham, MA, 02451, USA.
Pharm Res ; 40(8): 1901-1913, 2023 Aug.
Article em En | MEDLINE | ID: mdl-37280472
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Espectrometria de Massas em Tandem Limite: Humans Idioma: En Revista: Pharm Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Espectrometria de Massas em Tandem Limite: Humans Idioma: En Revista: Pharm Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos