Engineering the Intestinal Lymphatic Transport of Oral Nanoparticles to Educate Macrophages for Cancer Combined Immunotherapy.

Xu, Lu; Weng, Shufeng; Li, Shengqi; Wang, Ke; Shen, Yu; Xu, Ying; Tang, Cui; Yin, Chunhua

Xu, Lu; Weng, Shufeng; Li, Shengqi; Wang, Ke; Shen, Yu; Xu, Ying; Tang, Cui; Yin, Chunhua.

Afiliação

Xu L; State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200438, PR China.
Weng S; State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PR China.
Li S; State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200438, PR China.
Wang K; State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200438, PR China.
Shen Y; State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200438, PR China.
Xu Y; State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200438, PR China.
Tang C; State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200438, PR China.
Yin C; State Key Laboratory of Genetic Engineering, Department of Pharmaceutical Sciences, School of Life Sciences, Fudan University, Shanghai 200438, PR China.

ACS Nano ; 17(12): 11817-11837, 2023 06 27.

Article em En | MEDLINE | ID: mdl-37318192

Assuntos

Nanopartículas; Neoplasias de Mama Triplo Negativas; Humanos; Neoplasias de Mama Triplo Negativas/tratamento farmacológico; Macrófagos/metabolismo; Nanopartículas/uso terapêutico; Intestinos/patologia; Imunoterapia; Microambiente Tumoral; Linhagem Celular Tumoral

Palavras-chave

antitumor efficacy; combined immunotherapy; immune checkpoint inhibitor; lymphatic transport; macrophage; oral delivery; pDNA vaccine

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias de Mama Triplo Negativas Limite: Humans Idioma: En Revista: ACS Nano Ano de publicação: 2023 Tipo de documento: Article

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