Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site I<sub>Q</sub> Is Crucial for Oxygen Sensing in Rabbit and Human Ductus Arteriosus.

Read, Austin D; Bentley, Rachel E T; Martin, Ashley Y; Mewburn, Jeffrey D; Alizadeh, Elahe; Wu, Danchen; Lima, Patricia D A; Dunham-Snary, Kimberly J; Thébaud, Bernard; Sharp, Willard; Archer, Stephen L

Electron Leak From the Mitochondrial Electron Transport Chain Complex I at Site I_Q Is Crucial for Oxygen Sensing in Rabbit and Human Ductus Arteriosus.

Read, Austin D; Bentley, Rachel E T; Martin, Ashley Y; Mewburn, Jeffrey D; Alizadeh, Elahe; Wu, Danchen; Lima, Patricia D A; Dunham-Snary, Kimberly J; Thébaud, Bernard; Sharp, Willard; Archer, Stephen L.

Afiliação

Read AD; Department of Medicine Queen's University Kingston Ontario Canada.
Bentley RET; Department of Medicine Queen's University Kingston Ontario Canada.
Martin AY; Department of Medicine Queen's University Kingston Ontario Canada.
Mewburn JD; Department of Medicine Queen's University Kingston Ontario Canada.
Alizadeh E; Queen's CardioPulmonary Unit Queen's University Kingston Ontario Canada.
Wu D; Department of Medicine Queen's University Kingston Ontario Canada.
Lima PDA; Queen's CardioPulmonary Unit Queen's University Kingston Ontario Canada.
Dunham-Snary KJ; Department of Medicine Queen's University Kingston Ontario Canada.
Thébaud B; Department of Biomedical and Molecular Sciences Queen's University Kingston Ontario Canada.
Sharp W; Department of Cellular and Molecular Medicine University of Ottawa Ottawa Ontario Canada.
Archer SL; Children's Hospital of Eastern Ontario Research Institute Ottawa Ontario Canada.

J Am Heart Assoc ; 12(13): e029131, 2023 07 04.

Article em En | MEDLINE | ID: mdl-37345832

Assuntos

Canal Arterial; Animais; Humanos; Coelhos; Oxigênio; Espécies Reativas de Oxigênio/metabolismo; Transporte de Elétrons; Cálcio/metabolismo; Elétrons; Rotenona/metabolismo; Rotenona/farmacologia; Microtomografia por Raio-X

Palavras-chave

mitochondrial O2 sensor; patent ductus arteriosus; redox signaling; suppressor of site IIIQ0 electron leak (S3QEL); suppressor of site IQ electron leak (S1QEL)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Canal Arterial Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Am Heart Assoc Ano de publicação: 2023 Tipo de documento: Article

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