Circumstances, causes and timing of death in extremely preterm infants admitted to NICU: The EPIPAGE-2 study.
Acta Paediatr
; 112(10): 2066-2074, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37402152
ABSTRACT
AIM:
To describe the circumstances, causes and timing of death in extremely preterm infants.METHODS:
We included from the EPIPAGE-2 study infants born at 24-26 weeks in 2011 admitted to neonatal intensive care units (NICU). Vital status and circumstances of death were used to define three groups of infants alive at discharge, death with or without withholding or withdrawing life-sustaining treatment (WWLST). The main cause of death was classified as respiratory disease, necrotizing enterocolitis, infection, central nervous system (CNS) injury, other or unknown.RESULTS:
Among 768 infants admitted to NICU, 224 died among which 89 died without WWLST and 135 with WWLST. The main causes of death were respiratory disease (38%), CNS injury (30%) and infection (12%). Among the infants who died with WWLST, CNS injury was the main cause of death (47%), whereas respiratory disease (56%) and infection (20%) were the main causes in case of death without WWLST. Half (51%) of all deaths occurred within the first 7 days of life, and 35% occurred within 8 and 28 days.CONCLUSION:
The death of extremely preterm infants in NICU is a complex phenomenon in which the circumstances and causes of death are intertwined.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Unidades de Terapia Intensiva Neonatal
/
Lactente Extremamente Prematuro
Tipo de estudo:
Etiology_studies
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
Acta Paediatr
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
França