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Quality of Life and Gastrointestinal Symptoms in Long-term Survivors of Pancreatic Cancer Following Pancreatoduodenectomy.
Zhang, Chi; Zironda, Andrea; Vierkant, Robert A; Starlinger, Patrick; Warner, Susanne; Smoot, Rory; Kendrick, Michael; Cleary, Sean; Truty, Mark; Thiels, Cornelius.
Afiliação
  • Zhang C; Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ.
  • Zironda A; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester, MN.
  • Vierkant RA; Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN.
  • Starlinger P; Department of Quantitative Health Sciences, Mayo Clinic Rochester, Rochester, MN.
  • Warner S; Department of Surgery, Mayo Clinic Rochester, Rochester, MN.
  • Smoot R; Department of Surgery, Mayo Clinic Rochester, Rochester, MN.
  • Kendrick M; Department of Surgery, Mayo Clinic Rochester, Rochester, MN.
  • Cleary S; Department of Surgery, Mayo Clinic Rochester, Rochester, MN.
  • Truty M; Department of Surgery, Mayo Clinic Rochester, Rochester, MN.
  • Thiels C; Department of Surgery, Mayo Clinic Rochester, Rochester, MN.
Ann Surg ; 279(5): 842-849, 2024 May 01.
Article em En | MEDLINE | ID: mdl-37497660
OBJECTIVE: To describe long-term quality of life (QOL) and gastrointestinal (GI) symptoms in patients who underwent pancreatoduodenectomy for pancreatic cancer in the modern era. BACKGROUND: As advances in pancreatic cancer management improve outcomes, it is essential to assess long-term patient-reported outcomes after surgery. METHODS: Patients who underwent curative intent pancreatoduodenectomy for pancreatic cancer between January 2011 and June 2019 from a single center were identified. Patients alive ≥3 years after surgery were considered long-term survivors (LTS). LTS who were alive in June 2022 received a 55-question survey to assess their QOL (EORTC-QLQ-C30) and GI symptoms (EORTC-PAN26 and Problem Areas in Diabetes Questionnaire). Responses were compared against population norms. Clinicodemographic characteristics in LTS versus non-LTS and survey completion were compared. RESULTS: Six hundred seventy-two patients underwent pancreatoduodenectomy for pancreatic cancer; 340 were LTS. One hundred thirty-seven patients of the 238 eligible to complete the survey responded (response rate: 58%). Compared to the US general population, LTS reported significantly higher QOL (75 vs 64; P <0.001), less nausea/vomiting, pain, dyspnea, insomnia, appetite loss, and constipation, but more diarrhea (all P <0.001). Most patients (n=136/137, 99%) reported experiencing postoperative GI symptoms related to pancreatic insufficiency (n=71/135, 53%), reflux (n=61/135, 45%), and delayed gastric emptying (n=31/136, 23%). Most patients (n=113/136, 83%) reported that digestive symptoms overall had little to no impact on QOL, and 91% (n=124/136) would undergo surgery again. CONCLUSIONS: Despite known long-term complications following pancreatoduodenectomy, cancer survivors appear to have excellent QOL. Specific long-term gastrointestinal symptoms data should be utilized for preoperative education and follow-up planning.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Refluxo Gastroesofágico / Sobreviventes de Câncer Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Ann Surg Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Refluxo Gastroesofágico / Sobreviventes de Câncer Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Ann Surg Ano de publicação: 2024 Tipo de documento: Article