Novel 2-Sulfanylquinazolin-4(3<i>H</i>)-one Derivatives as Multi-Kinase Inhibitors and Apoptosis Inducers: A Synthesis, Biological Evaluation, and Molecular Docking Study.

Altharawi, Ali; Alanazi, Mohammed M; Alossaimi, Manal A; Alanazi, Ashwag S; Alqahtani, Safar M; Geesi, Mohammed H; Riadi, Yassine

Novel 2-Sulfanylquinazolin-4(3H)-one Derivatives as Multi-Kinase Inhibitors and Apoptosis Inducers: A Synthesis, Biological Evaluation, and Molecular Docking Study.

Altharawi, Ali; Alanazi, Mohammed M; Alossaimi, Manal A; Alanazi, Ashwag S; Alqahtani, Safar M; Geesi, Mohammed H; Riadi, Yassine.

Afiliação

Altharawi A; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11541, Saudi Arabia.
Alossaimi MA; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Alanazi AS; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh 84428, Saudi Arabia.
Alqahtani SM; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Geesi MH; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Riadi Y; Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.

Molecules ; 28(14)2023 Jul 20.

Article em En | MEDLINE | ID: mdl-37513420

Assuntos

Antineoplásicos; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Simulação de Acoplamento Molecular; Linhagem Celular Tumoral; Proliferação de Células; Ensaios de Seleção de Medicamentos Antitumorais; Antineoplásicos/química; Receptores ErbB/metabolismo; Doxorrubicina/farmacologia; Apoptose; Inibidores de Proteínas Quinases/química

Palavras-chave

apoptosis; cytotoxicity; molecular docking; protein kinases; quinazolin-4(3H)-one

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antineoplásicos Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Arábia Saudita

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