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Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.
Zhang, Qi; Li, He; Chen, Xuelan; Gu, Fan; Zhang, Lanxin; Zhang, Lu; Chen, Tong; Chen, Qiang; Meng, Wentong; Wu, Yu; Chang, Hong; Liu, Ting; Chen, Chong; Ma, Hongbing; Liu, Yu.
Afiliação
  • Zhang Q; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Li H; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Chen X; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Gu F; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Zhang L; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Zhang L; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Chen T; Sichuan Hua Xi Kindstar Medical Diagnostic Centre, Chengdu, Sichuan, China.
  • Chen Q; Sichuan Neo-Life Stem Cell Biotech Inc, Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China.
  • Meng W; Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
  • Wu Y; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Chang H; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Liu T; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Chen C; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Ma H; Department of Hematology, Institute of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
  • Liu Y; Department of Hematology and Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Blood ; 142(17): 1494-1499, 2023 10 26.
Article em En | MEDLINE | ID: mdl-37624915
Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Promielocítica Aguda Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Promielocítica Aguda Limite: Animals Idioma: En Revista: Blood Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China