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A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo.
Bestas, Burcu; Wimberger, Sandra; Degtev, Dmitrii; Madsen, Alexandra; Rottner, Antje K; Karlsson, Fredrik; Naumenko, Sergey; Callahan, Megan; Touza, Julia Liz; Francescatto, Margherita; Möller, Carl Ivar; Badertscher, Lukas; Li, Songyuan; Cerboni, Silvia; Selfjord, Niklas; Ericson, Elke; Gordon, Euan; Firth, Mike; Chylinski, Krzysztof; Taheri-Ghahfarokhi, Amir; Bohlooly-Y, Mohammad; Snowden, Mike; Pangalos, Menelaos; Nuttall, Barrett; Akcakaya, Pinar; Sienski, Grzegorz; Maresca, Marcello.
Afiliação
  • Bestas B; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Wimberger S; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Degtev D; Department of Chemistry & Molecular Biology, University of Gothenburg, Gothenburg, Sweden.
  • Madsen A; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Rottner AK; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Karlsson F; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Naumenko S; Data Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Cambridge, UK.
  • Callahan M; Department of Biostatistics, Harvard Chan School of Public Health, Boston, MA, USA.
  • Touza JL; Translational Genomics, Translational Medicine, R&D Oncology, AstraZeneca, Waltham, MA, USA.
  • Francescatto M; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Möller CI; Data Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Cambridge, UK.
  • Badertscher L; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Li S; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Cerboni S; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Selfjord N; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
  • Ericson E; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Gordon E; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Firth M; Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Chylinski K; Data Sciences and Quantitative Biology, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Cambridge, UK.
  • Taheri-Ghahfarokhi A; Vienna Biocenter Core Facilities, Vienna Biocenter (VBC), Vienna, Austria.
  • Bohlooly-Y M; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Snowden M; Translational Genomics, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Pangalos M; Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Nuttall B; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
  • Akcakaya P; Translational Genomics, Translational Medicine, R&D Oncology, AstraZeneca, Waltham, MA, USA.
  • Sienski G; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden.
  • Maresca M; Genome Engineering, Discovery Sciences, BioPharmaceuticals R&D Unit, AstraZeneca, Gothenburg, Sweden. grzegorz.sienski@astrazeneca.com.
Nat Commun ; 14(1): 5474, 2023 09 06.
Article em En | MEDLINE | ID: mdl-37673883
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Translocação Genética / Pró-Proteína Convertase 9 Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Translocação Genética / Pró-Proteína Convertase 9 Limite: Animals Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia