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Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms.
Wang, Chen; Gao, Ming-Qi.
Afiliação
  • Wang C; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China.
  • Gao MQ; Department of Clinical Pharmacology, School of Pharmacy, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. mqgao26@cmu.edu.cn.
Neurochem Res ; 49(1): 14-28, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37715823
Depression is the most prevalent mental disorder, affecting more than 300 million adults worldwide each year, which can lead to serious economic and social problems. Antidepressants are usually the first-line treatment for depression, however, traditional antidepressants on the market have the disadvantage of low remission rates and may cause side effects to patients, therefore, the current focus in the field of depression is to develop novel therapeutic agents with high remission rates and few side effects. In this context, the antidepressant effects of natural compounds have received attention. Baicalin (baicalein-7-O-glucuronide) and its aglycone baicalein (5,6,7-trihydroxyflavone) are flavonoid compounds extracted from the root of Scutellaria baicalensis. Although lacking the support of clinical data, they have been shown to have significantly promising antidepressant activity in many preclinical studies through various rodent models of depression. This paper reviews the antidepressant effects of baicalin and baicalein in experimental animal models, with emphasis on summarizing the molecular mechanisms of their antidepressant effects including regulation of the HPA axis, inhibition of inflammation and oxidative stress, reduction of neuronal apoptosis and promotion of neurogenesis, as well as amelioration of mitochondrial dysfunction. Controlled clinical trials should be conducted in the future to examine the effects of baicalin and baicalein on depression in humans.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Flavanonas / Depressão / Antidepressivos Tipo de estudo: Systematic_reviews Limite: Animals / Humans Idioma: En Revista: Neurochem Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Flavanonas / Depressão / Antidepressivos Tipo de estudo: Systematic_reviews Limite: Animals / Humans Idioma: En Revista: Neurochem Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China